Biochemical potential of Salvia sclarea L.: In vitro cultivation and chemical profiling approaches
Keywords:
Salvia sclarea L, in vitro propagation, biochemical profilingAbstract
Salvia sclarea L. is a medicinal plant known since ancient times for its pharmacological potential, due to its rich phytocompound profile, the essential oils, and the secondary metabolites it contains. In recent decades, there has been an increasingly emphasized trend towards reorientation to natural therapies, leveraging plant-derived pharmacological products, which tend to be milder and have a lower toxicological profile than synthetic counterparts. Given that the plant's phytochemical profile can vary due to external factors such as soil quality, climate, or season, it is necessary to optimize cultivation methods to ensure the production of plant materials that are rich in active compounds with significant pharmacological potential. This objective can be accomplished through in vitro cultures, which enable precise control over growth conditions. This study is grounded in an exhaustive literature review of Salvia sclarea L. and aims to explore its phytochemical composition and pharmacological effects. Additionally, the study investigates its potential for in vitro cultivation as a viable solution for standardized and sustainable production of bioactive compounds.
References
Ben Akacha, B.; Ben Hsouna, A.; Generalić Mekinić, I.; Ben Belgacem, A.; Ben Saad, R.; Mnif, W.; Kačániová, M.; Garzoli, S. (2023), Salvia officinalis L. and Salvia sclarea Essential Oils: Chemical Composition, Biological Activities and Preservative Effects against Listeria monocytogenes Inoculated into Minced Beef Meat. Plants, 12, 3385.
Ciocarlan, A., Hristozova, G., Aricu, A., Dragalin, I., Zinicovscaia, I., Yushin, N., Grozdov, D., Popescu, V. (2021), "Determination of the Elemental Composition of Aromatic Plants Cultivated Industrially in the Republic of Moldova Using Neutron Activation Analysis" Agronomy 11, no. 5: 1011.
Dancer, Stephanie J. (2004), How antibiotics can make us sick: the less obvious adverse effects of antimicrobial chemotherapy. The Lancet infectious diseases 4, no. 10: 611-619.
Fišar, Z., Hroudová, J., & Raboch, J. (2010), Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers. Neuroendocrinology letters, 31(5), 645.
Foley, M. J., Hedge, I. C., & Möller, M. (2008), The enigmatic Salvia tingitana (Lamiaceae): a case study in history, taxonomy and cytology. Willdenowia, 38(1), 41-59.
Godic, A., Poljšak, B., Adamic, M. and Dahmane, R., (2014), The role of antioxidants in skin cancer prevention and treatment. Oxidative medicine and cellular longevity, 1, p.860479.
Grandi, G., Ferrari, S., Xholli, A., Cannoletta, M., Palma, F., Romani, C., Volpe, A., & Cagnacci, A. (2012), Prevalence of menstrual pain in young women: what is dysmenorrhea? Journal of pain research, 5, 169–174.
Green, B. N., Johnson, C. D., Egan, J. T., Rosenthal, M., Griffith, E. A., & Evans, M.W. (2012), Methicillin-resistant Staphylococcus aureus: an overview for manual therapists. Journal of chiropractic medicine, 11(1), 64–76.
Hasnain, A., Naqvi, S. A. H., Ayesha, S. I., Khalid, F., Ellahi, M., Iqbal, S., Hassan, M. Z., Abbas, A., Adamski, R., Markowska, D., Baazeem, A., Mustafa, G., Moustafa, M., Hasan, M. E., & Abdelhamid, M. M. A. (2022), Plants in vitro propagation with its applications in food, pharmaceuticals and cosmetic industries; current scenario and future approaches. Frontiers in plant science, 13, 1009395.
Herraiz, T., & Guillén, H. (2018), Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. BioMed research international, 2018, 4810394.
Hill-Eubanks, D. C., Werner, M. E., Heppner, T. J., & Nelson, M. T. (2011), Calcium signaling in smooth muscle. Cold Spring Harbor perspectives in biology, 3(9), a004549.
Itani, R., Soubra, L., Karout, S., Rahme, D., Karout, L., & Khojah, H. M. J. (2022), Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates. Korean journal of family medicine, 43(2), 101–108.
Kačániová, M., Vukovic, N. L., Čmiková, N., Galovičová, L., Schwarzová, M., Šimora, V., Kowalczewski, P. Ł., Kluz, M. I., Puchalski, C., Bakay, L., & Vukic, M. D. (2023), Salvia sclarea Essential Oil Chemical Composition and Biological Activities. International journal of molecular sciences, 24(6), 5179.
Kuźma, L., Kalemba, D., Rózalski, M., Rózalska, B., Wieckowska-Szakiel, M., Krajewska, U., & Wysokińska, H. (2009), Chemical composition and biological activities of essential oil from Salvia sclarea plants regenerated in vitro. Molecules (Basel, Switzerland), 14(4), 1438–1447.
Latthe, P. M., Champaneria, R., & Khan, K. S. (2011). Dysmenorrhoea. BMJ clinical evidence, 2011, 0813.
Nouri, F., Karami, P., Zarei, O., Kosari, F., Alikhani, M. Y., Zandkarimi, E., Rezazadeh Zarandi, E., & Taheri, M. (2020), Prevalence of Common Nosocomial Infections and Evaluation of Antibiotic Resistance Patterns in Patients with Secondary Infections in Hamadan, Iran. Infection and drug resistance, 13, 2365–2374.
Okwu, M. U., Olley, M., Akpoka, A. O., & Izevbuwa, O. E. (2019), Methicillin-resistant Staphylococcus aureus (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review. AIMS microbiology, 5(2), 117–137.
Pant, P., Pandey, S., & Dall'Acqua, S. (2021), The influence of environmental conditions on secondary metabolites in medicinal plants: A literature review. Chemistry & Biodiversity, 18(11), e2100345.
Pence, V. C. (2011), Evaluating costs for the in vitro propagation and preservation of endangered plants. In Vitro Cellular & Developmental Biology-Plant, 47, 176-187.
Phillips, G. C., & Garda, M. (2019), Plant tissue culture media and practices: an overview. In Vitro Cellular & Developmental Biology-Plant, 55, 242-257.
Proctor, M., & Farquhar, C. (2006), Diagnosis and management of dysmenorrhoea. Bmj, 332(7550), 1134-1138.
Randjelović, M., Branković, S., Jovanović, M., Kitić, N., Živanović, S., Mihajilov-Krstev, T., Miladinović, B., Milutinović, M., & Kitić, D. (2023), An In Vitro and In Silico Characterization of Salvia sclarea L. Methanolic Extracts as Spasmolytic Agents. Pharmaceutics, 15(5), 1376.
Shahrajabian, M. H., Kuang, Y., Cui, H., Fu, L., & Sun, W. (2023), Metabolic changes of active components of important medicinal plants on the basis of traditional Chinese medicine under different environmental stresses. Current Organic Chemistry, 27(9), 782-806.
Sikora, A., & Zahra, F. (2023), Nosocomial Infections. In StatPearls. StatPearls Publishing.
Twaij, B. M., Jazar, Z. H., & Hasan, M. N. (2020), Trends in the use of tissue culture, applications and future aspects. International Journal of plant biology, 11(1), 8385.
Wong, Jennifer, Yi-Fen Chiang, Yin-Hwa Shih, Chun-Hui Chiu, Hsin-Yuan Chen, Tzong-Ming Shieh, Kai-Lee Wang, Tsui-Chin Huang, Yong-Han Hong, Shih-Min Hsia. (2020), Salvia sclarea L. Essential Oil Extract and Its Antioxidative Phytochemical Sclareol Inhibit Oxytocin-Induced Uterine Hypercontraction Dysmenorrhea Model by Inhibiting the Ca2+–MLCK–MLC20 Signaling Cascade: An Ex Vivo and In Vivo Study, Antioxidants 9, no. 10: 991.
Yücel, Y. Y., & Özdemir, E. (2023), Determination of antioxidant activity of Salvia sclarea L. and its inhibitory effects on acetylcholinesterase and monoamine oxidase A. Fabad Journal of Pharmaceutical Sciences, 48(2), 255-264.
Zhang, P.Y., Xu, X. and Li, X.C., (2014), Cardiovascular diseases: oxidative damage and antioxidant protection. European Review for Medical & Pharmacological Sciences, 18(20).
